New research suggests that selective serotonin reuptake inhibitors (SSRIs), the most commonly used class of depression drugs, are associated with a higher risk of bone fractures. The study was published in the OnlineFirst portion of the IADR/AADR Journal of Dental Research (JDR).
Because bone metabolism is influenced by osseointegration, researchers used osseointegrated dental implants as a measure for risk of bone failure associated with SSRI use. The study included 490 patients with dental implants from January 2007 and January 2013. In total, there were 916 reported implants. The participants were followed for 6 years and seven months.
At the conclusion of the study, there were 38 failed implants and 784 were successful in the group that did not use SSRIs. Among the group that did use SSRIs, 10 implants failed and 84 succeeded. Overall, researchers found a failure rate of 4.6 percent amongst non-SSRI users and 10.6 percent in the group that did take SSRIs. The risk of implant failure increased with small implant diameters, bone augmentation and smoking habits.
Last year, a study showed that antidepressants users had a higher chance of developing type 2 diabetes. Research has also linked antidepressants to significant weight gain, but other studies that explored this association also found that other factors have been involved.