In what is being called “the first in-depth analysis of the global impact of birth defects,” by a number of sources like HealthDay News, the March of Dimes is reporting that over 8 million children worldwide are born with a serious genetic or partly genetic birth defect each year.

The report, titled The March of Dimes Global Report on Birth Defects: The Hidden Toll of Dying and Disabled Children, states at least 3.3 million children under 5 years old die every year from serious birth defects. More The March of Dimes Reports Over Eight Million Children Born with Birth Defects Worldwide Each Year

An international scientific conference, Occupational and Environmental Exposures of Skin to Chemicals-2005, is taking place this week in Stockholm, Sweden. More than 200 participants from around the world will discuss skin exposure to toxic, irritant, and allergenic chemicals in the workplace and the non-occupational environment. The group will also discuss ways to minimize exposure and prevent hazardous effects.

The development of new products and chemicals also presents the problem of determining what effect exposure to them may have on humans. This can be quite problematic since some toxic substances take a very long time to cause detectable injuries. For example, in the case of asbestos it takes between 20 and 50 years for mesothelioma to develop. Thus, merely because a new product does not cause immediate harm there is no reason to celebrate. Many "miracle" products, chemicals, and drugs have proven to be highly toxic only after the public has been exposed to what they believed was a safe substance for a considerable length of time.

Mesothelioma is a highly aggressive cancer found in the lining of the chest, the abdominal cavity, and area around the heart.

It is primarily caused by exposure to airborne asbestos particles and has a latency period of between 30 and 40 years (some experts put the latency period at up to 50 years). This form of cancer, for which there is currently no cure, is particularly lethal and resistant to all conventional therapies.

A five-year animal (mouse) study by researchers from several countries, however, has found that a vitamin E-related compound known as alpha-TOS may kill mesothelioma cells. The compound also halted the growth of mesothelioma tumors and showed promise with respect to suppressing tumors associated with melanoma and breast, lung, and colon cancer.

Dr. Jiri Neuzil of Griffith University (Gold Coast), who headed the study, hopes to begin human trials within two years. Although Dr. Neuzil is encouraged by the results, he is cautiously optimistic since “in the past many experiments showing promise in mice have completely failed in humans.” One very positive finding in this study was that alpha-TOS selectively pursued mesothelioma cells and destroyed them while causing little, if any damage to normal cells.

Although alpha-TOS is already taken orally by many people as a health supplement, it loses its cancer fighting quality when it is converted to vitamin E by the digestive system. Dr. Neuzil made a cynical observation, however, when he stated that the pharmaceutical industry might not take on alpha-TOS as a cancer cure because the compound cannot be patented.