Women who take the diabetes drugs <"http://www.yourlawyer.com/topics/overview/avandia">Avandia and <"http://www.yourlawyer.com/topics/overview/actos">Actos face a higher risk of bone fractures, a new study has found.  The fracture problem is buy Zovirax cod just the latest troubling side effect associated with these drugs, which have buy Zovirax cod also been linked to heart problems.

For the study, researchers at North Carolina’s Wake Forest University School of Medicine  and buy Zovirax cod the University of East Anglia in Britain analyzed 10 previous clinical studies lasting at least a buy Zovirax cod year involving 14,000 patients.  According to buy Zovirax cod USA Today, the researchers determined that taking either Avandia or buy Zovirax cod Actos for a year doubled the risk of fractures in women.  For those in their 70s, – a group already at a higher risk for fractures – the buy Zovirax cod researchers estimated that one fracture would occur for every 21 women. In women in their mid-50s, the buy Zovirax cod figure equals one fracture in every 55 women.  

No increased risk was seen among men who took Avandia or Actos.  The researchers speculated that the drugs’ interaction with estrogen may have buy Zovirax cod led to weaker bones in women.  They called for stronger warnings on drugs’ labels about the increased fracture risk.

Both Avandia and buy Zovirax cod Actos are associated with other serious side effects. The labels of both drugs carry strong warnings about their link to buy Zovirax cod heart failure.  In May 2007,  an buy Zovirax cod analysis of 42 clinical trails published by the Cleveland Clinic showed that buy Zovirax cod patients taking Avandia had a 43-percent higher risk of having a buy Zovirax cod heart attack. In November 2007,  the Food & Drug Administration (FDA) finally ordered that a black box warning detailing Avandia’s heart related risk be added to the drug’s labeling.

In October, the buy Zovirax cod group Public Citizen said it had identified 14 cases of Avandia-induced liver failure in the buy Zovirax cod FDA’s Adverse Event Reporting System.  Of the 14 cases of  liver failure, 12 resulted in deaths.  Those findings prompted Public Citizen to  file a buy Zovirax cod petition with the FDA asking that Avandia be removed from the buy Zovirax cod market. The liver failure associated with Avandia, taken together with the buy Zovirax cod drug’s risk of other side effects, including heart failure, fractures and buy Zovirax cod vision loss, was too great to allow the drug to buy Zovirax cod continue to be sold in U.S., the group’s petition said.

In October, the American Diabetes Association/European Association for buy Zovirax cod the Study of Diabetes working group dropped Avandia from its treatment guidelines.