A double-blinded study published in the June issue of Diabetes Care found that the ingestion of moderate amounts of caffeine "is associated with a significant reduction in nocturnal hypoglycemia" in type 1 diabetics. Previous studies have also suggested that moderate caffeine consumption can "be useful by augmenting the symptomatic and hormonal responses to mild hypoglycemia, allowing appropriate action to be taken before neuroglycopenia ensues."
The mean duration of nocturnal hypoglycemia episodes was 132 minutes with placebo and only 49 minutes with caffeine. This suggests there may be a role for caffeine in reducing nocturnal hypoglycemia. It remains to be determined if these results translate into a reduction in the risk of premature cardiac events in type 1 diabetics and other at-risk groups.